Scheriproct N suppositories are more suitable for treating internal piles. Scheriproct ointment can be applied to the anal area to relieve external piles and can also be inserted into the back passage using the applicator to relieve internal piles.

Providing short-term relief (5 to 7 days) from the symptoms of piles (haemorrhoids) and anal itching.

Scheriproct N suppositories contains :

• Prednisolone hexanoate – On local application, exerts a powerful anti-inflammatory action which is superior to that of both cortisone and hydrocortisone. Its effects include a reduction of capillary dilatation, intercellular oedema and inflammatory infiltration within tissues, and the inhibition of vascularisation.
• Cinchocaine hydrochloride – Has a local anaesthetic effect on mucous membranes and, in combination with prednisolone hexanoate, provides a quick relief of painful and pruritic symptoms.

In-vitro and in-vivo investigations with corticosteroid esters (halogenated and non- halogenated corticoids) have shown that these compounds are split extremely rapidly into the corticoid and fatty acid by the esterases which are ubiquitously present in the body. For this reason, after topical application and percutaneous absorption of prednisolone hexanoate, the steroid alcohol, prednisolone, becomes systemically available.

Warnings: In infants, long-term continuous therapy with topical corticosteroids should be avoided. Occlusion is not appropriate on the perineum. Adrenal suppression can occur, even without occlusion. As with all topical steroids, there is a risk of developing skin atrophy following extensive therapy. The application of unusually large quantities of topical corticoids may result in the absorption of systemically active amounts of corticoid. Secondarily infected dermatoses definitely require additional therapy with antibiotics or chemotherapeutic agents. This treatment can often be topical, but for heavy infections systemic antibacterial therapy may be necessary. If fungal infections are present, a topically active antimycotic should be applied.

The excipient (hard fat) in Scheriproct N suppositories may reduce the effectiveness of latex products such as condoms.